Melanoma Genomics

Melanoma Genetics/Genomics

Gene mutations represent a major driving force in the onset and progression of melanoma. Consequently many genes are being investigated for their role in melanomagenesis, including not only inherited genes but also genetic defects that are acquired due to environmental factors, such as excessive sun exposure. The field of melanoma genetics thus encompasses genes in familial melanoma through to ...

Melanoma Genomics and Immunotherapy.

Over the last decade the molecular characterization of melanoma has progressed. Since a majority of melanoma cases arise from repeated intermittent ultra violet radiation (UVR) exposure, the role of UVR has been evaluated extensively. Recent work has identified two mechanisms in which the carcinogenesis of melanoma may result; Ultra violet radiation has been demonstrated to lead to down regulat...

Genomics of Human Malignant Melanoma

Malignant melanoma is considered the most aggressive form of skin cancer. The incidence rate of the disease has steadily risen over the past few decades throughout the world. If melanoma is diagnosed early, it can be cured by surgical resection, but as soon as the first distant metastasis appears, the disease becomes one of the most aggressive types of metastatic, chemoresistant lesions. Cutane...

Integrative Genomics Identifies Gene Signature Associated with Melanoma Ulceration

BACKGROUND Despite the extensive research approaches applied to characterise malignant melanoma, no specific molecular markers are available that are clearly related to the progression of this disease. In this study, our aims were to define a gene expression signature associated with the clinical outcome of melanoma patients and to provide an integrative interpretation of the gene expression -,...

Nodular Melanoma